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Venetoclax tablets 100mg/tablet, 120 tablets/box
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- Contraindications
- Warnings and Precautions
• Tumor Lysis Syndrome (TLS): predicts TLS; assesses risk in all patients. Antihyperuric acid medications are used in advance and ensure adequate hydration. As the overall risk increases, more stringent measures (intravenous rehydration, frequent monitoring, hospitalization) are taken.
• Neutropenia: Monitor blood counts. Dosing was interrupted and resumed at the same or reduced dose. Consider supportive care measures.
• Infection: Monitor for signs and symptoms of infection and treat them promptly. For Grade 3 and Grade 4 infections, dosing should be interrupted until resolution and resumed at the same or reduced dose.
• Immunizations: Do not receive live attenuated vaccines before, during, or after treatment with LUCIVENET until B cells have recovered.
• Embryo-fetal toxicity: May cause embryo-fetal harm. Women of childbearing potential are advised to be aware of the potential risks to the fetus and to use effective contraception.
• LUCIVENET in combination with bortezomib plus dexamethasone is not recommended for the treatment of patients with multiple myeloma, except in controlled clinical trials. - Medication risks
- Adverse Reactions
In CLL/SLL, the most common adverse reactions (≥ 20%) when LUCIVENET is used in combination with or as monotherapy with obituzumab or rituximab are neutropenia, thrombocytopenia, anemia, diarrhea, nausea, upper respiratory tract infection, cough, musculoskeletal pain, fatigue, and edema.
In AML, the most common adverse reactions (≥ 30%) when used in combination with azacitidine or decitabine or low-dose cytarabine are nausea, diarrhea, thrombocytopenia, constipation, neutropenia, febrile neutropenia, fatigue, vomiting, edema, pyrexia, pneumonia, dyspnea, bleeding, anemia, rash, abdominal pain, sepsis, musculoskeletal pain, dizziness, cough, oropharyngealgia, and hypotension.
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