Cabozantinib Cabozantinib 20mg/capsule 90 capsules/bottle Lao United Pharmaceutical [Logistics aging 7-14 days]

Medication Safety Tips

Use this product according to its instructions, medical advice, and your health needs. Shipping is arranged after payment once the order meets dispatch requirements.

Contraindications

Warnings and Precautions
1. Cardiotoxicity
Cabotinib also has some cardiac toxicity, manifested as chest tightness, palpitations, dyspnea, etc., and can be prevented by taking cardioprotective agents, such as coenzyme Q10.
Recommended dosage for coenzyme Q10: 30-60 mg per day for average human health care; 60-120 mg per day for people at high risk of cardiovascular disease, including patients with Blood Pressure; 200-400 mg per day for patients with heart failure or ischemic (oxygen) heart disease, or 2-3 doses for those taking more than 60 mg per day.
2. Indications for permanent discontinuation
Severe bleeding, myocardial infarction, cerebral infarction, thromboembolism, Blood Pressure crisis, nephrotic syndrome, severe hepatitis, mandibular necrosis, gastrointestinal perforation, and fistula during treatment. A permanent discontinuation is required.

Medication risks

Side effects and adverse reactions
The most common (> 20% incidence) side effects and adverse reactions of cabotinib are:
Diarrhea, stomatitis, hand-foot-skin syndrome (PPEs), weight loss, loss of appetite, nausea, asthenia, mouth pain, hair discoloration, taste disorders, Blood Pressure, abdominal pain, constipation.
The most common (> 25% incidence) laboratory abnormalities caused by cabotinib are:
AST increased, ALT increased, lymphopenia, Alp increased, hypocalcemia, neutropenia, thrombocytopenia, hypophosphatemia, hyperbilirubinemia.
The most common (> 5% incidence) grade 3-4 side effects and adverse reactions to cabotinib are:
Diarrhea, hand-foot-skin syndrome (PPEs), lymphopenia, hypocalcemia, fatigue, Blood Pressure, asthenia, elevated Alt, weight loss, stomatitis, loss of appetite.
The most common side effects and adverse effects of cabotinib leading to permanent discontinuation are:
Hypocalcemia, elevated lipase, hand-foot skin reaction (PPEs), diarrhea, fatigue, Blood Pressure, nausea, pancreatitis, formation of tracheal fistula and vomiting.